Patient Information: Diffuse Large B Cell Lymphoma

What is diffuse large B cell lymphoma?

  • Germinal center B-cell-like (GCB) subtype;
  • Activated B-cell-like (ABC) subtype

What are the symptoms of diffuse large B cell lymphoma?

  • Fever
  • Night sweats
  • Unexplained weight loss
  • Fatigue
  • Loss of appetite
  • Shortness of breath
  • Pain

How is diffuse large B cell lymphoma diagnosed?

  • Blood tests e.g. complete blood count (CBC), lactate dehydrogenase level
  • Whole body CT scan
  • Positron emission tomography scan(PET)/CT scan
  • Lumbar puncture
  • Bone marrow biopsy

What are the stages of diffuse large B cell lymphoma?

  • Stage I — disease in a single lymph node region/lymph structure/extranodal site
  • Stage II — disease in two or more lymph node regions on the same side of the diaphragm
  • Stage III — disease in lymph node regions or structures on both sides of the diaphragm
  • Stage IV — disease in a number of organs/tissue other than lymph node regions or structures, such as liver and bone marrow

What is the survival rate for diffuse large B cell lymphoma?

What are diffuse large B cell lymphoma treatment guidelines?

  • Chemotherapy — drugs that preferably interfere with cells that are rapidly growing and making copies of themselves as compared to normal cells. This mostly impacts cancer cells, but as a side effect, also rapidly dividing cells such as those found in bone marrow, hair and the gastrointestinal tract’s lining.
  • Immunotherapy — drugs that are made up of antibodies that target specific types of cells. In the case of DLBCL this is B cells.

The role of clinical trials in diffuse large B cell lymphoma

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